Coccidiosis is one of the most frequent enteric diseases in intensive poultry production. Its impact on intestinal integrity, feed conversion, and mortality is well known, which has led to the prolonged use of coccidiostats as a preventive measure. However, regulatory pressure, the emergence of resistance, and the need to reduce residues have sparked debate over sustainable alternative strategies.

The current challenge lies in maintaining intestinal integrity and productive efficiency without relying exclusively on pharmacological programmes. A complementary and/or alternative approach is the use of natural compounds that stimulate local intestinal immunity, promote disruption of the coccidia life cycle, and support faster epithelial recovery following Eimeria challenge.

Some of these compounds, such as immunostimulant pronutrients, work by enhancing the expression of key interleukins involved in the elimination of intracellular pathogens (IL-1, IL-12, IL-18), boosting the activity of macrophages, NK cells and T lymphocytes, and prolonging the specific immune response against coccidia. Trials have shown reduced severity of caecal lesions, lower oocyst counts, and improvements in feed conversion, final weight, and mortality rates. In this context, Alquernat Zycox, based on intestinal pronutrients, is proposed as a natural tool for prevention or reinforcement programmes in coccidiosis control.