{"id":62709,"date":"2026-05-12T09:53:12","date_gmt":"2026-05-12T07:53:12","guid":{"rendered":"https:\/\/biovet-alquermes.com\/?p=62709"},"modified":"2026-05-12T11:39:08","modified_gmt":"2026-05-12T09:39:08","slug":"next-generation-preservatives-for-cereals-and-feed","status":"publish","type":"post","link":"https:\/\/biovet-alquermes.com\/en\/2026\/05\/12\/next-generation-preservatives-for-cereals-and-feed\/","title":{"rendered":"Next-generation preservatives for cereals and feed"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#5e5e5e\" class=\"has-inline-color\">Evaluation of the efficacy of Alquermold Natural Plus, a new natural-based preservative technology, against the main microbiological challenges in feed<\/mark><\/strong><\/p>\n<\/blockquote>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"2358\" height=\"1103\" src=\"https:\/\/biovet-alquermes.com\/wp-content\/uploads\/2026\/05\/CONSERVANTES-DE-NUEVA-GENERACION-PARA-CEREAL-Y-ALIMENTO-BALANCEADO-copia.jpg\" alt=\"Evaluation of the efficacy of Alquermold Natural Plus, a new natural-based preservative technology, against the main microbiological challenges in feed\" class=\"wp-image-62704\"\/><\/figure>\n\n\n\n<p>Preserving feed consists of maintaining its characteristics, i.e., preventing the loss of nutrients and energy value caused by the action of microorganisms (bacteria and fungi) present in the feed. Preserving these nutritional and energy properties is essential to achieve good productive parameters while simultaneously preventing important pathologies.<\/p>\n\n\n\n<p>The preservation of cereals and compound feed is carried out through the inclusion of products that minimize this deterioration \u2014 preservatives \u2014 which also help prevent digestive infectious diseases and other derived problems, such as mycotoxicosis.<\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#689037\" class=\"has-inline-color\">I. Analysis of the most common preservatives for feed and raw materials<\/mark><\/strong><\/p>\n\n\n\n<p>The most common preservatives on the market can be divided into three main types: organic acids, formaldehyde, and natural preservatives.<\/p>\n\n\n\n<p>The first group has been used for decades to preserve both raw materials and compound feed. Their mechanism is based on reducing the intracellular pH of pathogens to inhibit their metabolic processes and, therefore, their multiplication. In other words, they mainly exert a bacteriostatic and fungistatic effect. Formaldehyde is usually applied to grains for the control, among others, of <em>Salmonella<\/em>, a bacterium of great concern to poultry and swine industries due to its consequences for animals and the zoonotic potential of some strains.<\/p>\n\n\n\n<p>Finally, some natural preservatives have emerged in the industry, standing out for achieving equal or, in many cases, superior efficacy compared to the previously mentioned solutions. In this regard, a technology has been developed based on the synergy between cineole, cimenol ring, and isopropyl methyl-phenol, botanical molecules which, when combined with citric acid, are capable of eliminating a wide variety of microorganisms that cause feed deterioration through membrane disruption.<\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#689037\" class=\"has-inline-color\">II. Organic acids: characteristics and limitations<\/mark><\/strong><\/p>\n\n\n\n<p>Organic acids inhibit microbial growth in feed by reducing the internal pH of bacteria and fungi, thereby reducing their enzymatic activity to minimal levels and limiting their ability to reproduce. These products prevent the multiplication of microorganisms but do not eliminate them completely.<\/p>\n\n\n\n<p>Their spectrum of action is more or less limited: some acids are effective only against specific groups of microorganisms (i.e. gram-positive bacteria). The combination of propionic acid with formic acid is the most commonly used, as it broadens the preservative\u2019s spectrum of action.<\/p>\n\n\n\n<p>The main limitations of these products are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>They inhibit but do not completely eliminate microorganisms.<\/li>\n\n\n\n<li>Relatively short duration of effect: after approximately two months they lose efficacy, and microorganisms may use the acids as an energy source to multiply again.<\/li>\n\n\n\n<li>Limited spectrum of action: they are only effective against specific groups of microorganisms, meaning others may remain in the feed, or acid combinations become necessary.<\/li>\n\n\n\n<li>Corrosive potential: acids may damage machinery and their application can sometimes be hazardous for workers.<\/li>\n<\/ul>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#689037\" class=\"has-inline-color\">III. Formaldehyde: serious consequences for animals and humans<\/mark><\/strong><\/p>\n\n\n\n<p>Formaldehyde has a high capacity for controlling <em>Salmonella<\/em> and has therefore been widely used to eliminate this pathogen in grains and compound feed, as well as to prevent digestive infections.<\/p>\n\n\n\n<p>Its harmful effects on human and animal health have led to a progressive reduction in the availability of formaldehyde-based products for animal feed. This is because it is a toxic and irritating substance upon contact with skin and the respiratory tract, and is potentially carcinogenic for both humans and animals. Additionally, in the digestive tract, formaldehyde reacts with hydrochloric acid, causing thermal and chemical burns in the digestive epithelium, leading to significant deterioration of productive parameters <mark style=\"background-color:rgba(0, 0, 0, 0);color:#7e7e7e\" class=\"has-inline-color\">(Image 1)<\/mark>.<\/p>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:43% auto\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/biovet-alquermes.com\/wp-content\/uploads\/2026\/05\/Lesion-en-molleja-de-ave-que-ha-recibido-formaldehido-copia.jpg\" alt=\"Lesion in the gizzard of a bird exposed to formaldehyde. Burns distributed throughout the organ can be observed.\" class=\"wp-image-62708 size-full\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"has-text-color has-link-color wp-elements-a5a974e5eb883a50c4292322b9c7d44b\" style=\"color:#7e7e7e\"><em>Image 1. Lesion in the gizzard of a bird exposed to formaldehyde. Burns distributed throughout the organ can be observed.<\/em><\/p>\n<\/div><\/div>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#689037\" class=\"has-inline-color\">IV. Natural preservatives: synergy between antimicrobial phenolic compounds<\/mark><\/strong><\/p>\n\n\n\n<p>Natural preservatives represent a solution that has become more popular in industry compared to organic acids and formaldehyde, as they offer advantages that overcome the limitations of other preservatives. <strong><a href=\"https:\/\/biovet-alquermes.com\/en\/producto\/alquermold-natural-plus-2\/\" target=\"_blank\" rel=\"noreferrer noopener\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#689037\" class=\"has-inline-color\">Alquermold Natural Plus<\/mark><\/a><\/strong> is a clear example: a product based on the combination of cineole, cimenol ring, and isopropyl methyl-phenol, natural microbicidal molecules that synergistically eliminate a wide variety of microorganisms present in feed and cereals, including gram-positive and gram-negative bacteria, fungi, and yeasts.<\/p>\n\n\n\n<p>As it is a microbiocidal product, meaning it completely eliminates microorganisms, its efficacy lasts for a long time, allowing preservation of grains and compound feed for at least six months. Its mechanism is based on disruption of the cell membrane, leading to pathogen death.<\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#689037\" class=\"has-inline-color\">V. Recent scientific evaluation in collaboration with the University of Helsinki<\/mark><\/strong><\/p>\n\n\n\n<p>Recently, Biovet carried out an <em>in vitro<\/em> evaluation of the preservative efficacy of <strong>Alquermold Natural Plus<\/strong> compared with a combination of organic acids widely used in the industry.<\/p>\n\n\n\n<p>The objective of the study was to compare the percentage reduction of different microorganisms achieved by both preservatives. The effect against the most common sector-relevant microorganisms was also evaluated, including <em>Aspergillus, Clostridium, Escherichia coli, Salmonella, Pseudomonas, Rhizopus,<\/em> and <em>Fusarium<\/em>.<\/p>\n\n\n\n<p>For the experimental design, two types of substrates, ground corn and compound feed, were contaminated with 10<sup>6<\/sup> CFU\/g of these microorganisms. After product administration, microbial counts were performed at 24 hours and 7 days to assess microbial reduction.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1779\" height=\"1188\" src=\"https:\/\/biovet-alquermes.com\/wp-content\/uploads\/2026\/05\/1-1.jpg\" alt=\"CFU per gram of corn highly contaminated with different bacteria. Results shown 7 days after contamination.\" class=\"wp-image-62710\"\/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0);color:#7e7e7e\" class=\"has-inline-color\">Graph 1: CFU per gram of corn highly contaminated with different bacteria. Results shown 7 days after contamination.<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<p>Results showed that in the case of bacteria, <strong>Alquermold Natural Plus<\/strong> achieved notably lower bacterial counts on day 7 compared with the other preservative for each bacterium tested, even starting from high initial contamination. Compared to control, reductions were: 99.91% for <em>Clostridium<\/em>, 99.8% for <em>E. coli<\/em>, 99.93% for <em>Salmonella<\/em>, and 98.88% for <em>Pseudomonas<\/em>.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1779\" height=\"1188\" src=\"https:\/\/biovet-alquermes.com\/wp-content\/uploads\/2026\/05\/2-1.jpg\" alt=\"CFU per gram of corn highly contaminated with different fungi. Results shown 7 days after contamination.\" class=\"wp-image-62711\"\/><figcaption class=\"wp-element-caption\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#7e7e7e\" class=\"has-inline-color\"><em>Graph 2: CFU per gram of corn highly contaminated with different fungi. Results shown 7 days after contamination<\/em>.<\/mark><\/figcaption><\/figure>\n\n\n\n<p>Similarly, for fungi, <strong>Alquermold Natural Plus<\/strong> also achieved the lowest counts on day 7 after application in highly contaminated corn samples. Compared with control, reductions were: 91.13% for <em>Aspergillus<\/em>, 88.48% for <em>Fusarium<\/em>, and 91.07% for <em>Rhizopus<\/em>.<\/p>\n\n\n\n<p>Additionally, the preservative compared against <strong>Alquermold Natural Plus<\/strong> was administered at four times the dosage yet still produced lower bacterial and fungal reduction percentages than the natural product. These same results were observed in compound feed, with practically identical outcomes.<\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#689037\" class=\"has-inline-color\">VI. Added value of Alquermold Natural Plus: intestinal microbicidal effect<\/mark><\/strong><\/p>\n\n\n\n<p>An added value of this microbicidal technology is that, besides acting as a feed preservative, its efficacy persists in the digestive tract, acting as an intestinal antimicrobial and controlling pathogenic microorganisms that may colonize the intestine. Thus, animals consuming feed supplemented with <strong>Alquermold Natural Plus<\/strong> develop a more balanced intestinal flora while digestive infections are prevented.<\/p>\n\n\n\n<p>Field trials have shown that its inclusion in feed improves digestive flora balance without affecting beneficial flora such as <em>Lactobacillus spp<\/em>. Applications include prevention of infectious diseases associated with bacterial overgrowth in the intestine, such as necrotic enteritis (<em>Clostridium<\/em>), as well as reducing <em>Salmonella<\/em>, <em>E. coli<\/em>, and <em>Campylobacter<\/em> on farms.<\/p>\n\n\n\n<p>In a trial conducted at Universidad Cient\u00edfica del Sur (Lima, Peru), broilers were challenged with <em>Clostridium perfringens<\/em> to evaluate the capacity of <strong>Alquermold Natural Plus<\/strong> for prevention and treatment of necrotic enteritis and its impact on performance.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1779\" height=\"1188\" src=\"https:\/\/biovet-alquermes.com\/wp-content\/uploads\/2026\/05\/3-1.jpg\" alt=\"Results for body weight, FCR and mortality in broilers challenged with Clostridium perfringens, showing productive improvement with the use of Alquermold Natural Plus, both as prevention (powder mixed with feed) and treatment (liquid in drinking water when an outbreak is detected).\" class=\"wp-image-62712\"\/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0);color:#7e7e7e\" class=\"has-inline-color\">Graph 1: Results for body weight, FCR and mortality in broilers challenged with Clostridium perfringens, showing productive improvement with the use of <strong>Alquermold Natural Plus<\/strong>, both as prevention (powder mixed with feed) and treatment (liquid in drinking water when an outbreak is detected).<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<p>Administration of <strong>Alquermold Natural Plus<\/strong> as <strong>preventive<\/strong> and <strong>treatment<\/strong> <strong>reduced mortality<\/strong> compared to the infected control <strong>by 87.5% and 62.5%, respectively<\/strong>. In addition, the preventive group, despite the challenge, showed lower mortality than the negative control (non-infected) thanks to <strong>better control of digestive flora balance<\/strong>.<\/p>\n\n\n\n<p>Parameters such as <strong>uniformity<\/strong> also improved, being <strong>12% higher<\/strong> in the preventive group compared to the challenged control and 6% better than the negative control; <strong>carcass yield<\/strong> <strong>improved by 6.7%.<\/strong><\/p>\n\n\n\n<p>Regarding body weight and feed conversion ratio, after the <em>Clostridium perfringens<\/em> challenge, <strong>animals receiving Alquermold Natural Plus as prevention<\/strong> maintained productive performance and <strong>weighed nearly 300 grams more<\/strong> on day 42 compared with the infected group, <strong>with a 6.36% better feed conversion ratio.<\/strong><\/p>\n\n\n\n<p>Animals receiving the <strong>product in drinking water as treatment<\/strong> also <strong>improved<\/strong> daily <strong>weight gain<\/strong>, <strong>body weight<\/strong> and <strong>feed conversion <\/strong>compared to the infected group, demonstrating that <strong>Alquermold Natural Plus offers versatility<\/strong> for both prevention and treatment.<\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#689037\" class=\"has-inline-color\">VII. Conclusions<\/mark><\/strong><\/p>\n\n\n\n<p>Traditional preservatives are mainly based on combinations of different organic acids. However, they only exert an inhibitory effect on microorganisms without eliminating them, have limited spectrum and duration of action, and may be corrosive to facilities, animals and workers.<\/p>\n\n\n\n<p>In contrast, <strong><a href=\"https:\/\/biovet-alquermes.com\/en\/producto\/alquermold-natural-plus-2\/\" target=\"_blank\" rel=\"noreferrer noopener\">Alquermold Natural Plus<\/a><\/strong> is a natural-based technology that, being microbicidal, completely eliminates microorganisms with a broad spectrum of action lasting at least six months, and is neither corrosive nor harmful to animals, workers or machinery.<\/p>\n\n\n\n<p>Scientific results have shown that in feed preservation it achieves higher reduction percentages for all tested microorganisms, even at doses four times lower than products based on organic acids. This represents not only improved feed preservation but also significant economic benefits.<\/p>\n\n\n\n<p>Additionally, <strong>Alquermold Natural Plus<\/strong> remains effective after ingestion and controls enteric infections caused by <em>Salmonella<\/em>, <em>E. coli<\/em> or <em>Clostridium<\/em>, among others. In this sense, it can prevent important poultry sector diseases such as necrotic enteritis and improve performance and mortality rates. It has also been demonstrated that supplementation via drinking water as treatment helps control digestive challenges during outbreak situations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Evaluation of the efficacy of Alquermold Natural Plus, a new natural-based preservative technology, against the main microbiological challenges in feed Preserving feed consists of maintaining its characteristics, i.e., preventing the loss of nutrients and energy value caused by the action of microorganisms (bacteria and fungi) present in the feed. Preserving these nutritional and energy properties [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":62704,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2263],"tags":[2064,2067,1988],"class_list":["post-62709","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technical-articles","tag-alquermold-natural-en","tag-conservantes-en","tag-preservatives"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Next-generation preservatives for cereals and feed<\/title>\n<meta name=\"description\" content=\"Evaluation of the efficacy of Alquermold Natural Plus, a new natural-based preservative technology, against the main microbiological challenges in feed.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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