{"id":58078,"date":"2021-03-22T07:49:50","date_gmt":"2021-03-22T06:49:50","guid":{"rendered":"https:\/\/biovet-alquermes.com\/use-of-intestinal-optimizer-pronutrients-to-stimulate-the-intestinal-immunity-against-coccidiosis\/"},"modified":"2024-04-22T12:20:11","modified_gmt":"2024-04-22T10:20:11","slug":"use-of-intestinal-optimizer-pronutrients-to-stimulate-the-intestinal-immunity-against-coccidiosis","status":"publish","type":"post","link":"https:\/\/biovet-alquermes.com\/en\/2021\/03\/22\/use-of-intestinal-optimizer-pronutrients-to-stimulate-the-intestinal-immunity-against-coccidiosis\/","title":{"rendered":"Use of intestinal optimizer pronutrients to stimulate the intestinal immunity against coccidiosis"},"content":{"rendered":"<h2><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11796 size-full\" src=\"https:\/\/biovet-alquermes.com\/wp-content\/uploads\/2024\/04\/Use-of-intestinal-optimizer-pronutrients-to-stimulate-the-intestinal-immunity-against-coccidiosis.jpg\" alt=\"Use of intestinal optimizer pronutrients to stimulate the intestinal immunity against coccidiosis\" width=\"897\" height=\"600\" \/><\/h2>\n<h2>Traditional coccidiostats have certain limitations, such as resistance<\/h2>\n<p><a href=\"https:\/\/www.veterinariadigital.com\/en\/post_blog\/avian-coccidiosis\/\"><strong>Coccidiosis<\/strong><\/a><strong> is a parasitic disease of importance in the poultry sector <\/strong>affecting farms from all around the world with an <strong>important economic impact<\/strong> (1,2). For this reason,<strong> anticoccidial programs <\/strong>are systematically used to prevent this disease, which, even when subclinical, impairs performance and acts as a predisposing factor for other diseases.<\/p>\n<p>Since the 50\u2019s, <strong>synthetic and ionophore coccidiostats <\/strong>were added to the feed to prevent coccidiosis in broilers (3). They act<strong> directly on the parasite <\/strong>to limit their reproductive cycle, so that coccidia can no longer damage the gut mucosa.<\/p>\n<p>This direct action on coccidia has led to a <strong>rapid development of resistances <\/strong>(3), therefore, coccidiostats are frequently used in rotation and shuttle programs. Rotation programs changes to a different product or product combination after each flock, while shuttle programs alternate coccidiostats in the different production stages.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-11784 size-full alignleft\" src=\"https:\/\/biovet-alquermes.com\/wp-content\/uploads\/2024\/04\/limitation-of-coccidiostats.png\" alt=\"limitation of coccidiostats\" width=\"243\" height=\"368\" \/><\/p>\n<p>Besides the development of resistances, some coccidiostats have other <strong>disadvantages, <\/strong>such as the presence of <strong>residues in the meat and other products <\/strong>and, in the case of nicarbazin, <strong>hepatotocitity and decreased resistance of birds to heat stress.<\/strong><\/p>\n<p><strong>In some regions, <\/strong>such as the European Union or the United States,<strong> these drugs were already limited <\/strong>and there is a limited number of products available and less options for rotation and shuttle programs. Many important poultry producers from other countries may find it difficult to <strong>internationally export meat, <\/strong>and\/or need to <strong>make changes to meet the new market trends: <\/strong>part of the consumers would rather eat \u201cgreen\u201d products, which means that they would rather eat meat from animals raised with less antibiotics or in free-range systems.<\/p>\n<h3><strong>Intestinal optimizer pronutrients as a natural effective tool to control coccidiosis<\/strong><\/h3>\n<p>The raising market trend towards the consumption of natural food products, the loss of efficacy of the traditional solutions and the legal limitations call for a novel solution to replace coccidiostats: <a href=\"https:\/\/biovet-alquermes.com\/en\/producto\/alquernat-zycox-p-and-l\/\"><strong>intestinal optimizer pronutrients<\/strong><\/a>.<\/p>\n<p>Pronutrients are <strong>active molecules from plant extracts <\/strong>that stimulate cell physiology to optimize the organs and, this way, improve gut welfare, among other functions (6,7). Pronutrients that act as <strong>intestinal optimizers stimulate the immune local system of the intestines <\/strong>so that animal cells are ready to eliminate coccidia.<\/p>\n<h5>In vitro trials with intestinal optimizers pronutrients and its effect on coccidiosis<\/h5>\n<p>This mechanism of action, based on immune stimulation <strong>rather than on a direct effect on the parasite, <\/strong>prevents the development of resistances. It was described in <strong>molecular and cellular assays <\/strong>where these pronutrients increased <strong>interleukin IL-1, IL-12 and IL-18 expression <\/strong>in polymorphonuclear cells isolated from the gut, which are <strong>essential elements of anti-coccidia <\/strong>reactions in birds.<\/p>\n<p>When birds receive intestinal optimizers in the feed or the drinking water, their <strong>local immune system <\/strong>will be <strong>active at physiological levels <\/strong>and capable of eliminating coccidia to <strong>prevent the damage <\/strong>they produce.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11781 size-full\" src=\"https:\/\/biovet-alquermes.com\/wp-content\/uploads\/2024\/04\/Ciclo-reproductivo-de-los-coccidios.png\" alt=\"Ciclo reproductivo de los coccidios\" width=\"373\" height=\"281\" \/><\/p>\n<p style=\"text-align: center;\"><em>Image 1. Reproductive cycle of coccidia. Red cycle shows the most sensitive stage (sporozoites) to the activity of the immune system.<\/em><\/p>\n<h5>In vivo trials with intestinal conditioners pronutrients<\/h5>\n<p>This effect has been observed in many field trials following the scientific methodology that were conducted in different parts of the world in experimental and commercial poultry farms. They show that <strong>intestinal optimizers <\/strong>help animals to <strong>defend themselves from<\/strong> <strong>coccidiosis.<\/strong><\/p>\n<p>In a trial in broilers, pronutrients were more effective under different environmental conditions (wet and dry season) for a long period of time than a traditional anticoccidial program (8).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11785 size-full\" src=\"https:\/\/biovet-alquermes.com\/wp-content\/uploads\/2024\/04\/in-vivo-trials-with-intestinal-optimizers-pronutrients.png\" alt=\"in vivo trials with intestinal optimizers pronutrients\" width=\"495\" height=\"366\" \/><\/p>\n<p style=\"text-align: center;\"><em>Chart 1. Results of a trial with broilers in Panama where the efficiency index obtained with pronutrients in different seasons was compared with the average of prior cycles that were using traditional coccidiostats.<\/em><\/p>\n<p>In another trial, conducted in El Salvador, intestinal optimizers were included in the feed continuously and <strong>reduced mortality by 20,93% and improved uniformity by 5 points <\/strong>in week 16 of age, compared to a vaccine against coccidiosis (9).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11786 size-full\" src=\"https:\/\/biovet-alquermes.com\/wp-content\/uploads\/2024\/04\/in-vivo-trials-with-intestinal-optimizers-pronutrients-2.png\" alt=\"Pronutrients, natural solution to control coccidiosis\" width=\"711\" height=\"362\" \/><\/p>\n<p style=\"text-align: center;\"><em>Chart 2. Results of a trial conducted in pullets in El Salvador where intestinal optimizer pronutrients were compared with a vaccine against coccidiosis.<\/em><\/p>\n<p>In addition, <strong>pronutrients do not require withdrawal period. <\/strong>They act physiologically, do not cause negative effects and are completely safe. They <strong>meet the new consumers\u2019 requirements, <\/strong>and their availability is <strong>guaranteed in the future<\/strong>, since they are completely natural and already registered in countries with limitations such as the European Union and the United States.<\/p>\n<h3><strong>Pronutrients, natural solution to control coccidiosis<\/strong><\/h3>\n<p>Traditional products to prevent coccidiosis have important disadvantages, such as the development of resistances, which lead to the loss of efficacy and their limitation and\/or ban in several countries.<\/p>\n<p>Pronutrients are an <strong>effective and completely natural tool <\/strong>to boost the animal immune system, so that it can eliminate coccidia. They <strong>physiologically stimulate local immune cells in the gut <\/strong>and, since they do not directly affect the parasites, they do not create resistances.<\/p>\n<p><strong>Their efficacy has been broadly proved in <\/strong><em>in vitro <\/em>and in the field in different trials that show their long-term efficacy <strong>under different conditions in broilers, pullets, layers, and breeders. <\/strong>They were proved <strong>more efficient than traditional coccidiostats <\/strong>(+64 points in the efficiency index) <strong>and cocci vaccines <\/strong>(-21% mortality and +5 uniformity points).<\/p>\n<p style=\"text-align: center;\"><strong>Intestinal optimizers are pronutrients developed and patented by Biovet, S.A. marketed as Alquernat Zycox, available in premix and liquid presentations to be included in the feed or the drinking water.<\/strong><\/p>\n<p><strong>\u00a0<\/strong><strong style=\"color: #767676; font-size: 0.8125rem; letter-spacing: 0.15em; text-transform: uppercase;\">Bibliography<\/strong><\/p>\n<ul>\n<li>Coccidiosis aviar: situaci\u00f3n en Centroam\u00e9rica y Ecuador. Mecanismos naturales para su control. [Internet]. Veterinaria Digital. 2021. Available from: https:\/\/www.veterinariadigital.com\/articulos\/coccidiosis-aviar-situacion-en-centroamerica-y-ecuador-mecanismos-naturales-para-su-control\/<\/li>\n<li>Miguel JA, Asenjo B, Ciria J, Del Cacho E, Calvo JL. Comparison of control methods for coccidiosis in native Spanish \u201cCastellana Negra\u201d chickens. Spanish J Agric Res. 2008;6(4):531\u20136.<\/li>\n<li>Cervantes HM. Control de la coccidiosis en la avicultura comercial. In: XIV Seminario Internacional Patolog\u00eda y Producci\u00f3n Aviar. Athens, Georgia; 2018. p. 126\u201350.<\/li>\n<li>Ministerio de agricultura y ganader\u00eda R de E. Manual para el registro de empresas y productos de uso veterinario [Internet]. 2018. Available from: http:\/\/www.agrocalidad.gob.ec\/documentos\/MANUAL-PARA-EL REGISTRO-DE-EMPRESAS-Y-PRODUCTOS-DE-USO-VETERINARIO.pdf<\/li>\n<li>Anexo G. Instructivo para el registro de aditivos alimentarios. Rep. del Ecuador; 2020.<\/li>\n<li>Borrell J. Uso de pronutrientes de origen natural en veterinaria. RACVE (Real Acad Ciencias Vet Espa\u00f1a). 2005;<\/li>\n<li>Borrell J, Domenech C, Martin N, Tesouro A. Pronutrients use in poultry nutrition (S11-0224). In: XXV World\u2019s Poultry Congress [Internet]. Beijing, China; 2016. p. 97. Available from: http:\/\/www.wpsa.com\/images\/downloads\/tables_of_contents\/The Proceedings of WPC2016-Abstracts-20160920.pdf<\/li>\n<li>Estudio de la eficacia de pronutrientes optimizadores intestinales para controlar la aparici\u00f3n de coccidiosis en broilers [Internet]. 2018. Available from: https:\/\/www.veterinariadigital.com\/post_blog\/estudio-de-la-eficacia-de-pronutrientes-optimizadores-intestinales-para-controlar-la-aparicion-de-coccidiosis-en-broilers\/<\/li>\n<li>Pollitas: Adici\u00f3n de pronutrientes en la fase de recr\u00eda o levante [Internet]. 2020. Available from: https:\/\/www.veterinariadigital.com\/post_blog\/pollitas-adicion-de-pronutrientes-en-la-fase-de-recria-o-levante\/<\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pronutriens are an effective and completely natural tool to boost the animal immune system, so that it can eliminate coccidia. They physiologically stimulate local immune cells in the gut and, since they do not directly affect the parasites, they do not create resistances.<\/p>\n","protected":false},"author":1,"featured_media":36471,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1555,1918,1934],"tags":[1933,1725,1742,1922],"class_list":["post-58078","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-poultry","category-pronutrient","tag-additives-for-animal-nutrition","tag-alquernat-zycox","tag-coccidia","tag-featured"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Use of intestinal optimizer pronutrients to stimulate the intestinal immunity against coccidiosis<\/title>\n<meta name=\"description\" content=\"Pronutriens are an effective and completely natural tool to boost the animal immune system, so that it can eliminate coccidia. 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